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KMID : 1123920040180041111
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 4 p.1111 ~ p.1119
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The Effects of Anti-Alzheimer on CT105-induced PC 12 Cells by Corynoxeine Isolated from Uncariae Ramulus et Uncus
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Kang Hyung-Won
Kim Sang-Tae
Lyu Yeoung-Su
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Abstract
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In this study, we investigated that the effects of corynoxeine on the apoptosis by inducible CT105 in PC 12 cells and neuronpathogenic agent as CT105 confirmed with apoptosis, DNA fragmentation, neurite outgrowth and immunocytochemistry analysis This study examines whether corynoxeine have an anti-alzhmeimer agent by inhibition of apoptosis by CT105 and induces neurite outgrowth. Cytotoxicity was assessed in PC12 cell cultures by DNA fragmentation and measuring lactate dehydrogenase (LDH) in the culture media. The treatment of corynoxeine in exposure of cultures to CT105 and provided complete protection against cytotoxicity. CT105-induced cytotoxicity was blocked by apoptotsis, repaired by DNA fragmentation, neurite outgrowth and exposure to CT105 expression and regenerated with neurite outgrowth and immunocytochemistry by corynoxeine. These results indicate that in neuronal cell cultures, damage of T105, repaired excitotoxicity by corynoxeine and CT105-induced cytotoxicity is blocked primarily by the activation of anti-apoptosis.
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KEYWORD
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corynoxeine, Uncariae ramulus et uncus, cytotoxicity, apoptosis, CT105, APP, Alzheimer disease
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